#Topical stem cell treatment for hair loss skin#
Microneedle patches that introduce cerium nanoparticles into the skin are a promising strategy to reverse balding for androgenetic alopecia patients, the researchers say. Finally, the researchers found that the cerium-containing microneedle patches resulted in faster mouse hair regrowth with similar coverage, density and diameter compared with a leading topical treatment and could be applied less frequently. These mice also had fewer oxidative stress compounds in their skin.
#Topical stem cell treatment for hair loss Patch#
However, those treated with the nanoparticle patch showed faster signs of hair undergoing a transition in the root, such as earlier skin pigmentation and higher levels of a compound found only at the onset of new hair development. Both applications stimulated the formation of new blood vessels around the mice's hair follicles. The team tested control patches and the cerium-containing ones on male mice with bald spots formed by a hair removal cream. Then they made the dissolvable microneedle patch by pouring a mixture of hyaluronic acid - a substance that is naturally abundant in human skin - and cerium-containing nanoparticles into a mold. So, the researchers wanted to design a minimally invasive way to deliver cerium-containing nanoparticles near hair roots deep under the skin to promote hair regrowth.Īs a first step, the researchers coated cerium nanoparticles with a biodegradable polyethylene glycol-lipid compound.
However, these nanoparticles cannot cross the outermost layer of skin.
Previously, Fangyuan Li, Jianqing Gao and colleagues determined that cerium-containing nanoparticles can mimic enzymes that remove excess reactive oxygen species, which reduced oxidative stress in liver injuries, wounds and Alzheimer's disease. In addition, an accumulation of reactive oxygen species in the scalp can trigger the untimely death of the cells that form and grow new hair. Hair loss is permanent for people with the condition because there aren't enough blood vessels surrounding the follicles to deliver nutrients, cytokines and other essential molecules.
The most common hair loss condition is called androgenic alopecia, also known as male- or female- pattern baldness.
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